HLA Variants Key to Predicting Kidney Transplant Outcomes

Researchers led by King’s College London’s Graham Lord conducted a genome-wide association study of organ donor and recipient DNA from about 8,000 pairs of donors and recipients. As they reported in the American Journal of Transplantation this week, they replicated known links between the HLA region and outcomes, but were unable to find any genetic link to outcomes outside that region.

“[W]e identified that this area of DNA alone can tell us whether the match between a kidney donor and recipient will work in the long term,” Lord said in a statement. “This has the potential to improve outcomes for transplant patients and deliver treatments that are more personalized to the health needs of individual patients.”

Read More

After double lung transplants, an opera singer is given the chance for Act III

Published on December 25, 2017

Charity Tillemann-Dick’s life sounds like the plot of a grand opera: She was diagnosed with high blood pressure in the lungs at the age of 20. By the time she was 26, she had to go through a double lung transplant. But it didn’t take. Through all this, she never stopped doing what she loves most: Singing. Dr. Jon LaPook reports on her own Encore.

Read More